Boone
$$College-town hub around Appalachian State: King Street restaurants and bars, breweries, gear shops, the Greenway and the nearest base for Rocky Knob.
Stay here if: You want the most food, nightlife, outfitters and central access to hiking, mountain biking and the Parkway.
Blowing Rock
$$$Polished resort village (elevation 3,517 ft) beside the Blue Ridge Parkway, Moses Cone and Price Lake, with boutiques and inns.
Stay here if: You want Parkway access, carriage-trail walks and a quieter, upscale base; about 15 minutes from Boone.
Banner Elk
$$-$$$Small valley town (3,895 ft) with Lees-McRae College, craft breweries and restaurants, between the Beech and Sugar ski areas.
Stay here if: You are here to ski Beech or Sugar, or want Avery County access to Grandfather Mountain and Linville Gorge.
Beech Mountain / Sugar Mountain
$$-$$$Slope-side ski villages: Beech Mountain is the highest town east of the Rockies (5,506 ft per Wikipedia intro; other figures conflict); Sugar Mountain village sits at 4,557 ft beside the resort. Rentals, condos and cabins.
Stay here if: You want ski-in or short-drive access in winter, or the Beech bike park in summer.
Foscoe
$$Rural valley community on NC 105 between Boone and Grandfather Mountain with riverside cabins and outfitters along the Watauga River.
Stay here if: You want a quiet cabin base close to Grandfather Mountain, the Profile Trail and the Watauga River.
Seven Devils
$$Small mountain town (about 3,960 ft) near Boone and Banner Elk; home to Hawksnest snow tubing and ziplining.
Stay here if: You want a mid-point cabin or house rental between Boone and the ski areas.
Linville / Grandfather Village
$$$Historic resort community (founded 1883) at the foot of Grandfather Mountain with country clubs and a quiet, residential feel.
Stay here if: You want to be at the base of Grandfather Mountain and the Linville Falls area, with seasonal, low-key lodging.